Publications
2025
47. Jinglin Fu*, Qiaochu Zhang, Shiming Liu, Derek Puyat, Akshay Shah, Alireza Ebrahimimojarad, and Sung Won Oh ” Rapid Amplification and Detection of Single-Stranded Nucleic Acids for Point-of-Care Diagnosis”, Small Methods 2025, 2401733. https://doi.org/10.1002/smtd.202401733
46. Jinglin Fu*, Anthony Monte Carlo and Doris Zheng “Incorporation of NUPACK-based Computation into Classroom and Laboratory Teaching of Nucleic Acids Hybridization for Undergraduate Biochemistry”, Journal of Chemical Education, published online. https://doi.org/10.1021/acs.jchemed.4c01051
2024
45. Sayed Mehedi Azim, Aravind Balasubramanyam, Sheikh Rabiul Islam, Jinglin Fu and Iman Dehzangi* “Explainable Machine Learning Model to Accurately Predict Protein-Binding Peptides”, Algorithms, acceptance for publication.
44. Qiaochu Zhang, Alireza Ebrahimimojarad, Akshay Shah and Jinglin Fu* “Characterization of DNA Origami Nanostructures for Size and Concentration by Dynamic Light Scattering and Nanoparticle Tracking Analysis”, ChemRxiv 2024, Version 1. This is a preprint without peer review.
https://chemrxiv.org/engage/chemrxiv/article-details/664b8e9891aefa6ce1882471
43. Z Wang, S Kulkarni, J Nong, M Zamora, A Ebrahimimojarad, E Hood, T Shuvaeva, M Zaleski, D Gullipalli, E Wolfe, C Espy, E Arguiri, Y Wang, OA Marcos-Contreras, W Song, VR Muzykantov, J Fu, R Radhakrishnan, JW Myerson, JS Brenner* A percolation-type criticality threshold controls immune protein coating of surfaces, Cell, accepted.
42. Alireza Ebrahimimojarad, Zhicheng Wang, Qiaochu Zhang, Akshay Shah, Jacob Brenner and Jinglin Fu* “A Robust and Efficient Method to Purify DNA-scaffolded Nanostructures by Gravity-Driven Size Exclusion Chromatography” Langmuir 2024, 40, 16, 8365–8372. https://doi.org/10.1021/acs.langmuir.3c03778
2023
41. Derek Puyat, Sung Won Oh, Shiming Liu and Jinglin Fu* “Competitive aptamer switch for modulating ligand binding affinity” Advanced Agrochem2023, 2, 264-268. Published online. https://doi.org/10.1016/j.aac.2023.06.004
2022
40. Zhicheng Wang, Ezry St. Iago-Mcrae, Alireza Ebrahimimojarad, Sung Won Oh and Jinglin Fu* “Modulation of Enzyme Cascade Activity by Local Substrate Enrichment and Exclusion on DNA Nanostructures” Langmuir 2022, 38, 12594–12601. https://doi.org/10.1021/acs.langmuir.2c02064
39. Jinglin Fu and Fei Zhang “Self-assembly of Nucleic Acids: From Structures to Biomedical Applications” Current Topics in Medicinal Chemistry 2022, 22, 639. DOI: 10.2174/156802662208220503005318
38. Anthony Monte Carlo and Jingiln Fu “Inactivation Kinetics of G-Quadruplex/Hemin Complex and Optimization for More Reliable Catalysis”, ChemPlusChem 2022,87, e2022000. https://doi.org/10.1002/cplu.202200090.
37. Jinglin Fu and Kaitlyn Nguyen “Reduction of Promiscuous Peptides-Enzyme Inhibition and Aggregation by Negatively Charged Biopolymers”, ACS Applied Bio Materials 2022, https://doi.org/10.1021/acsabm.1c01128.
36. Ezry Santiago-McRae, Sung Won Oh, Anthony Monte Carlo, Omri Bar, Emily Guan, Doris Zheng, Catherine Grgicak and Jinglin Fu “Rapid Nucleic Acid Reaction Circuits for Point-Of-Care Diseases Diagnosis”, Current Topics in Medicinal Chemistry 2022, 8, 686 – 698DOI: 10.2174/1570163819666220207114148
35. Sung Won Oh, Zhicheng Wang and Jinglin Fu* “DNA Nano-scaffolds for Multienzyme Systems Assembly” Methods in Molecular Biology 2022, 2487, 93-112. doi: 10.1007/978-1-0716-2269-86.
2020
34. Jinglin Fu*, Zhicheng Wang, Xiaohua Anna Liang, Sung Won Oh and Ting Zhang “DNA-Scaffolded Proximity Assembly and Confinement of Multienzyme Reactions” Topics in Current Chemistry 2020, published online, DOI: 10.1007/s41061-020-0299-3.
2019
33. Jinglin Fu “Biomimetic assembly of multienzyme reactions on DNA nanostructures”, Research Outreach 2019, 109. DOI: 10.32907/RO-109-1013
Available at: https://researchoutreach.org/articles/biology/biomimetic-assembly-multienzyme-reactions-dna-nanostructures/
32. Ting Zhang, Jia Nong, Nouf Alzahrani, Zhicheng Wang, Tristan Meier, Dong Gyu Yang, Yonggang Ke, Yinghui Zhong, Jinglin Fu “Self-Assembly of DNAMinocycline Complexes by Metal Ions with Controlled Drug Release” ACS Applied Materials & Interfaces 2019, 11, 29512-29521.
31. Jinglin Fu*, Sung Won Oh, Kristin Monckton, Georgia Arbuckle-Keil, Yonggang Ke and Ting Zhang “Biomimetic Compartments Scaffolded by Nucleic Acid Nanostructures” Small 2019, 1900256. https://doi.org/10.1002/smll.201900256.
2018
30. Ge, Zhilei; Fu, Jinglin; Liu, Minghui; Jiang, Shuoxing; Andreoni, Alessio; Zuo, Xiaolei; Liu, Yan; Yan, Hao; Fan, Chunhai ” Constructing Submonolayer DNA Origami Scaffold on Gold Electrode for Wiring of Redox Enzymatic Cascade Pathways”, ACS Applied Materials & Interfaces 2019, 11, 3881–13887. DOI: 10.1021/acsami.8b12374
29. Sung Won Oh, Adriana Pereira, Ting Zhang and Jinglin Fu* “DNA-Mediated Proximity Assembly Circuit for Actuating Biochemical Reactions”, Angewandte Chemie 2018, 57, 13086-13090. doi: 10.1002/anie.201806749.
28. Yuhe R. Yang, Jinglin Fu, Shaun Wootten, Xiaodong Qi, Minghui Liu, Hao Yan and Yan Liu* “2D Enzyme Cascade Network with Efficient Substrate Channeling by Swinging Arms”, ChemBioChem 2018, 19, 212-216.
27. Scott Huston, John Collins, Fangfang Sun, Ting Zhang, Timothy D. Vaden, Y. –H. Percival Zhang and Jinglin Fu* “An Activity Transition from NADH Dehydrogenase to NADH Oxidase during Protein Denaturation”, BioTechnology and Applied Biochemistry 2018, 65, 286-293.
2017
26. John Collins, Ting Zhang, Sung Won Oh, Robert Maloney and Jinglin Fu* “DNA-Crowded Enzyme Complexes with Enhanced Activities and Stabilities”, Chem Comm. 2017, 53, 13059–13062
25. Jinglin Fu, Luca Larini, Anthony J. Cooper, John W. Whittaker, Azka Ahmed, Junhao Dong, Minyoung Lee and Ting Zhang “Computational and Experimental Analysis of Short Peptide Motifs for Enzyme Inhibition”, PLoS ONE 2017, https://doi.org/10.1371/journal.pone.0182847.
24. Jinglin Fu* “Microarray Selection of Cooperative Peptides for Modulating Enzyme”, Microarrays, 2017, 6(2), 8; doi:10.3390/microarrays6020008
23. Jinglin Fu*, Gabriele Stankeviciute, Sung Won Oh, John Collins Yinghui Zhong and Ting Zhang “Self-assembled Nucleic Acid Nanostructures for Cancer Theranostics Medicines”, Current Topics in Medicinal Chemistry 2017, 17, 1-14.
2016
22. Jinglin Fu* and Tianran Li “Spatial Organization of Enzyme Cascade on a DNA Origami Nanostructure”, invited book chapter for “3D DNA Nanostructures — Methods and Protocols”, Methods in Molecular Biology, 2016, Humana Press.
21. Jinglin Fu*, Renee Yang, Soma Dhakal, Zhao Zhao, Minghui Liu, Ting Zhang, Nils Walter and Hao Yan “Assembly of Multi-Enzyme Complexes on DNA Nanostructures”, Nature Protocols 2016, 11,2243–2273.
20. John Collins, Ting Zhang, Scott Huston, Fangfang Sun, Percival Zhang and Jinglin Fu* “A Hidden Transhydrogen Activity of A FMN-Bound Diaphorase under Anaerobic Conditions” PLoS One 2016, DOI:10.1371/journal.pone.0154865.
19. Minghui Liu, Jinglin Fu, Xiaodong Qi, Shaun Wootten, Neal W. Woodbury, Yan Liu, Hao Yan* “A three-enzyme pathway with an optimized geometric arrangement to facilitate substrate transfer” ChemBioChem 2016, 17, 1097-1101.
18. Zhao Zhao+, Jinglin Fu*+, Soma Dhakal, Alexander Johnson-Buck, Minghui Liu, Ting Zhang, Neal Woodbury, Yan Liu, Nils G. Walter and Hao Yan* “Nano-caged Enzymes with Enhanced Activity and Increased Stability against Protease Digestion”, Nature Communications 2016, 7, 10619.
News: Chemical nanocages: New technique advances synthetic biology. https://phys.org/news/2016-02-chemical-nanocages-technique-advances-synthetic.html
2015
17. Jinglin Fu*, Bryce Sadtler, Ian Wheeldon, Zhuangqun Huang “How Can We Learn from Biology to Create New Functional Materials?” (Editorial comment) Advanced Science Engineering and Medicine 2015, 7, 1007-1008.
16. Ting Zhang, John Collins, Georgia A. Arbuckle-Keil and Jinglin Fu* “DNA-Directed Assembly of Conductive Nanomaterials” Advanced Science Engineering and Medicine 2015, 7, 1019-1032.
15. Ting Zhang, John Collins, Jinglin Fu* “Single-Molecule Sensing of Biomolecular Interactions on DNA Nanostructures” Current Nanoscience 2015,11, 727-735.
https://www.benthamscience.com/journal/abstracts.php?journalID=cnano&articleID=131025
2014
14. Jinglin Fu*, Yuhe Renee Yang, Alexander Johnson-Buck, Minghui Liu, Yan Liu, Nils G. Walter, Neal W. Woodbury and Hao Yan* “Multi-enzyme complexes on DNA scaffolds capable of substrate channeling with an artificial swinging arm” Nature Nanotechnology 2014, 9, 531–536.
News: DNA nanotechnology places enzyme catalysis within an arm’s length. https://www.sciencedaily.com/releases/2014/05/140525155310.htm
https://www.nature.com/nnano/journal/vaop/ncurrent/full/nnano.2014.100.html
13. Ting Zhang, Jinglin Fu, Qun Fang* “Improved high-speed capillary electrophoresis system using a short capillary and picoliter-scale translational spontaneous injection” Electrophoresis 2014, 35, 2361-2369.
Before joining Rutgers
12. Minghui Liu, Jinglin Fu*, Christian Hejesen, Yuhe Yang, Neal W. Woodbury, Kurt Gothelf, Yan Liu and Hao Yan* “A DNA tweezers-actuated enzyme nanoreactor” Nature Communications 2013, 4:2127 doi: 10.1038/ncomms3127
News: Tiny tweezers allow precision control of enzymes. https://phys.org/news/2013-07-tiny-tweezers-precision-enzymes.html#nRlv
11. Jinglin Fu, Minghui Liu, Yan Liu and Hao Yan* “Spatially-interactive Biomolecular Networks Organized by Nucleic Acid Nanostructures”, Accounts of Chemical Research 2012, 8, 1215-1226.
10. Jinglin Fu & Hao Yan* “Controlled drug release by a nanorobot”, Nature Biotechnology 2012, 30, 407–408.
9. Jinglin Fu, Minghui Liu, Yan Liu, Neal Woodbury and Hao Yan* “Inter-enzyme Substrate Diffusion for An Enzyme Cascade Organized on Spatially Addressable DNA Nanostructures”, Journal of American Chemical Society 2012, 134, 5516-5519. Highlighted by JACS as Spotlights article https://pubs.acs.org/doi/abs/10.1021/ja302665h;
8. Jinglin Fu, Jeremy Reinhold and Neal W. Woodbury* “Peptide-modified Surfaces for Enzyme Immobilization”, PLoS ONE 2011, 6, e18692.
7. Matthew P. Greving, Paul Belcher, Chris Diehnelt, Jack Emery, Jinglin Fu, Stephen A. Johnston and Neal W. Woodbury*, “Thermodynamic Additivity of Sequence Variations: An Algorithm for Creating High Affinity Peptides Without Large Libraries or Structural Information.”, PLoS ONE 2010, 5, e15432.
6. Jinglin Fu, Katherine Cai, Stephen A. Johnston and Neal W. Woodbury* “Exploring Peptide Space for Enzyme Modulators”, Journal of American Chemical Society 2010, 132, 6419-6424.
5. Ting Zhang, Qun Fang, Wenbin Du and Jinglin Fu “Microfluidic Picoliter-Scale Translational Spontaneous Sample Introduction for High-Speed Capillary Electrophoresis”, Analytical Chemistry 2009, 81, 3693-3698.
4. Huijun Dong, Jinglin Fu, Yongquan Li and Junyun Jiang “Microfluidic chip for detecting the expression of green fluorescent protein in Bacillus subtilis” Chinese Journal of Biotechnology 2009, 25, 1077-1081.
3. Jinglin Fu, Qun Fang, Ting Zhang, Xinhua Jin and ZhaoLun Fang, “Laser Induced Fluorescence Detection System for Microfluidic Chips Based on An Orthogonal Optical Arrangement,” Analytical Chemistry 2006, 78, 3827-3834.
2. Jinglin Fu, Qun Fang, and Yanzhen Huang, “A Simple Laser Induced Fluorescence Detection System for Microfluidic Chips”, Chemical Journal of Chinese Universities 2004, 25(z1), 95-96.
1. Qun Fang, Gungming Xu, Jinglin Fu, Zhijian Jia and Xuefeng Yin, “Integrated Microfluidic Chip Analyzer for Amino Acids Analysis”, Chemical Journal of Chinese Universities 2004, 25(z1),